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Effect of mTHPC-mediated photodynamic therapy on 5-fluorouracil resistant human colorectal cancer cells

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Abstract

The primary or acquired cancer chemoresistance is a major problem in the treatment of cancer patients. It could be overcome by non-overlapping treatment regimens such as photodynamic therapy (PDT). PDT is based on the oxidation of cellular components which occurs when a light-excited photosensitizer generates reactive oxygen species (ROS). In this study the effect of mTHPC mediated PDT (mTHPC-PDT) on 5-FU resistant colorectal cancer (CRC) cells HCT116 was investigated. The results show that mTHPC-PDT overcomes 5-FU resistance and is effective against chemoresistant colorectal carcinoma cells.

Graphical abstract: Effect of mTHPC-mediated photodynamic therapy on 5-fluorouracil resistant human colorectal cancer cells

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Publication details

The article was received on 18 Jan 2017, accepted on 24 Apr 2017 and first published on 25 Apr 2017


Article type: Paper
DOI: 10.1039/C7PP00014F
Citation: Photochem. Photobiol. Sci., 2017, Advance Article
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    Effect of mTHPC-mediated photodynamic therapy on 5-fluorouracil resistant human colorectal cancer cells

    E. Kukcinaviciute, A. Sasnauskiene, D. Dabkeviciene, V. Kirveliene and V. Jonusiene, Photochem. Photobiol. Sci., 2017, Advance Article , DOI: 10.1039/C7PP00014F

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