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A convergent synthesis of vinyloxyimidazopyridine via Cu(I)-catalyzed three-component coupling

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Abstract

The synthesis of vinyloxyimidazopyridine with complete regio- and stereoselectivity has been achieved by the Cu(I)-catalyzed three-component coupling of 2-aminopyridine, 2-oxoaldehyde and alkyne. This protocol is operationally very simple and has much potential for the synthesis of heteroarylated vinyl ethers from basic chemicals. Steroidal imidazopyridinyl vinyl ether was obtained successfully from ethynylestradiol.

Graphical abstract: A convergent synthesis of vinyloxyimidazopyridine via Cu(i)-catalyzed three-component coupling

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Publication details

The article was received on 22 Nov 2017, accepted on 07 Dec 2017 and first published on 07 Dec 2017


Article type: Paper
DOI: 10.1039/C7OB02883K
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A convergent synthesis of vinyloxyimidazopyridine via Cu(I)-catalyzed three-component coupling

    S. Samanta, S. Mondal and A. Hajra, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02883K

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