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Synthesis of spiro-4H-pyrazole-oxindoles and fused 1H-pyrazoles via divergent, thermally induced tandem cyclization/migration of alkyne-tethered diazo compounds

Abstract

A thermally induced, substrate-dependent reaction of alkynyl diazo compounds has been developed. These transformations produce spiro-4H-pyrazole-oxindoles and fused 1H-pyrazoles in good to high yields from the corresponding alpha-cyano and alpha-sufonyl diazo compounds. Sailent features of this reaction include: excellent chemoselectivity and atom-economy, mild reaction conditions, simple purification and potential for large scale production.

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Publication details

The article was received on 16 Nov 2017, accepted on 05 Dec 2017 and first published on 06 Dec 2017


Article type: Communication
DOI: 10.1039/C7OB02802D
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Synthesis of spiro-4H-pyrazole-oxindoles and fused 1H-pyrazoles via divergent, thermally induced tandem cyclization/migration of alkyne-tethered diazo compounds

    X. Xu, C. Zhang, S. Dong, Y. Zheng, C. He, J. Che, J. Zhen and L. Qiu, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB02802D

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