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Issue 48, 2017
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Hydrogen-free reductive amination using iron pentacarbonyl as a reducing agent

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Abstract

We developed solvent-free reductive amination without an external hydrogen source using iron pentacarbonyl as a reducing agent. Neither a catalyst nor any other additives were employed. Various types of substrates are suitable for the reaction, including those with low reactivity, e.g. benzophenone. Among others, the protocol tolerates bromo-, cyano-, benzyloxy-, pyrimidyl and styryl moieties.

Graphical abstract: Hydrogen-free reductive amination using iron pentacarbonyl as a reducing agent

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Publication details

The article was received on 15 Nov 2017, accepted on 23 Nov 2017 and first published on 23 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02795H
Citation: Org. Biomol. Chem., 2017,15, 10164-10166
  • Open access: Creative Commons BY license
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    Hydrogen-free reductive amination using iron pentacarbonyl as a reducing agent

    O. I. Afanasyev, D. L. Usanov and D. Chusov, Org. Biomol. Chem., 2017, 15, 10164
    DOI: 10.1039/C7OB02795H

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