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Issue 48, 2017
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(+)- and (−)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungus Ascomycota sp. SK2YWS-L

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Abstract

A pair of novel enantiomeric polyketide dimers, (+)- and (−)-ascomlactone A (1a and 1b), were obtained from a mangrove endophytic fungus Ascomycota sp. SK2YWS-L. The structures were elucidated based on spectroscopic methods, and the absolute configurations were determined by X-ray diffraction and electronic circular dichroism (ECD) calculations. Ascomlactone A possessed an unprecedented polymerization system, which constructed an unusual nine-membered lactone ring between the monomers. A possible biogenetic pathway was proposed. Both 1a and 1b exhibited significant inhibitory effects against α-glucosidase with IC50 values of 63.7 and 27.9 μM, respectively. A further docking study provided an inside perspective of the action in α-glucosidase.

Graphical abstract: (+)- and (−)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungus Ascomycota sp. SK2YWS-L

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Publication details

The article was received on 03 Nov 2017, accepted on 21 Nov 2017 and first published on 21 Nov 2017


Article type: Paper
DOI: 10.1039/C7OB02707A
Citation: Org. Biomol. Chem., 2017,15, 10276-10280
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    (+)- and (−)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungus Ascomycota sp. SK2YWS-L

    Z. Liu, S. Chen, P. Qiu, C. Tan, Y. Long, Y. Lu and Z. She, Org. Biomol. Chem., 2017, 15, 10276
    DOI: 10.1039/C7OB02707A

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