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Pd-Catalyzed Regioselective Intramolecular Dehydrogenative C-5 Cross Coupling in an N-substituted Pyrrole-Azole System

Abstract

Functionalized polycyclic pyrrole-azole structures possessing fused six membered and seven membered rings were directly synthesized via ligand-enabled Pd-catalyzed site selective intramolecular cross coupling of N-substituted pyrrole-azole. The C5-H activation in the presence of reactive C2-H remains a challenge to be addressed, which was targeted to be resolved through the present approach by specifically generating the cyclized products ranging from 83-100% selectivity. The featured methodology provides a novel disconnection for the synthesis of pyrrole containing alkaloids and medicinal compounds.

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Publication details

The article was received on 31 Oct 2017, accepted on 09 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7OB02676E
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Pd-Catalyzed Regioselective Intramolecular Dehydrogenative C-5 Cross Coupling in an N-substituted Pyrrole-Azole System

    R. P. Singh, K. N. Tripathi and D. Ray, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB02676E

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