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Nickel Catalyzed Acceptorless Dehydrogenative Approach to Quinolines

Abstract

A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o-aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare nickel catalyst [Ni(MeTAA)], featuring a tetraaza macrocyclic ligand (tetramethyltetraaza[14]annulene (MeTAA)). A wide variety of substituted quinolines were synthesized in high yields starting from readily available o-aminobenzylalcohols and ketones or secondary alcohols. A few controlled reactions were carried out to establish the acceptorless dehydrogenative nature of the reactions.

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Publication details

The article was received on 30 Oct 2017, accepted on 05 Dec 2017 and first published on 05 Dec 2017


Article type: Paper
DOI: 10.1039/C7OB02670F
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Nickel Catalyzed Acceptorless Dehydrogenative Approach to Quinolines

    S. Parua, R. Sikari, S. Sinha, S. Das, G. Chakraborty and N. D. Paul, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB02670F

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