Jump to main content
Jump to site search


Pd-Catalyzed one-pot sequential cross-coupling reactions of tetrabromothiophene

Author affiliations

Abstract

Unsymmetrical one-pot sequential cross-coupling reactions of sterically hindered tetrabromothiophene with arylboronic acid and an alkyne/alkene to afford selective bi-, tri-, and tetrasubstituted aryl/alkynyl-thiophenes with the aid of a palladium catalyst were described. The reaction proceeds via a site-selective Suzuki/Sonogashira coupling, followed by selective Sonogashira, Suzuki and Heck coupling reactions. This methodology has demonstrated an important framework for the synthesis of organic scaffolds.

Graphical abstract: Pd-Catalyzed one-pot sequential cross-coupling reactions of tetrabromothiophene

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Oct 2017, accepted on 17 Nov 2017 and first published on 17 Nov 2017


Article type: Paper
DOI: 10.1039/C7OB02601C
Citation: Org. Biomol. Chem., 2017, Advance Article
  •   Request permissions

    Pd-Catalyzed one-pot sequential cross-coupling reactions of tetrabromothiophene

    K. M. Saini, R. K. Saunthwal and A. K. Verma, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02601C

Search articles by author

Spotlight

Advertisements