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A Brønsted acid-promoted asymmetric intramolecular allylic amination of alcohols

Abstract

Reported herein is a chiral Brønsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile synthesis of a range of biologically interesting chiral 2-substituted hydroquinolines in up to 90% yield and with up to 93% ee. Furthermore, a significant effect of N-protecting group were observed in this asymmetric process.

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Publication details

The article was received on 22 Oct 2017, accepted on 06 Dec 2017 and first published on 07 Dec 2017


Article type: Communication
DOI: 10.1039/C7OB02599H
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    A Brønsted acid-promoted asymmetric intramolecular allylic amination of alcohols

    J. Zhou and H. Xie, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB02599H

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