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Issue 47, 2017
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Rhodium-catalyzed benzoisothiazole synthesis by tandem annulation reactions of sulfoximines and activated olefins

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Abstract

Rhodium(III)-catalyzed N-directed ortho C–H activation reactions have been developed for the synthesis of unique heterocyclic benzoisothiazoles. Herein, this novel tandem annulation approach can efficiently construct benzoisothiazole compounds from free NH-sulfoximines and alkenes via C–H activation, olefination and subsequent intramolecular aza-Michael cyclization.

Graphical abstract: Rhodium-catalyzed benzoisothiazole synthesis by tandem annulation reactions of sulfoximines and activated olefins

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Publication details

The article was received on 19 Oct 2017, accepted on 15 Nov 2017 and first published on 16 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02586F
Citation: Org. Biomol. Chem., 2017,15, 9983-9986
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    Rhodium-catalyzed benzoisothiazole synthesis by tandem annulation reactions of sulfoximines and activated olefins

    Y. Li and L. Dong, Org. Biomol. Chem., 2017, 15, 9983
    DOI: 10.1039/C7OB02586F

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