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Pyrazole synthesis via a cascade Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones

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Abstract

An efficient approach for the preparation of pyrazoles via a Pd(II)/Cu(I)-catalyzed Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones has been established. In this study, we firstly report the strategic use of a Sonogashira reaction to construct pyrazole rings in a one step operation. With a broad range of functional group tolerance, bioactive 3-CF3 pyrazoles can also be synthesized easily through this domino coupling/cyclization sequence.

Graphical abstract: Pyrazole synthesis via a cascade Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones

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Publication details

The article was received on 18 Oct 2017, accepted on 29 Nov 2017 and first published on 29 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02576A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Pyrazole synthesis via a cascade Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones

    Y. Yang, Z. Hu, R. Li, Y. Chen and Z. Zhan, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C7OB02576A

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