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Synthesis of 2,2-bis(pyridin-2-yl amino)cyclobutanols and their conversion into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones

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Abstract

A two-step protocol is presented for the preparation of 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones from 2-hydroxycyclobutanone and some 2-aminopyridines via a catalyst-free synthesis of 2,2-bis(pyridin-2-ylamino)cyclobutanols followed by Dess–Martin periodinane mediated ring expansion.

Graphical abstract: Synthesis of 2,2-bis(pyridin-2-yl amino)cyclobutanols and their conversion into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones

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Publication details

The article was received on 17 Oct 2017, accepted on 08 Nov 2017 and first published on 08 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02567J
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Synthesis of 2,2-bis(pyridin-2-yl amino)cyclobutanols and their conversion into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones

    L. Ghisu, N. Melis, F. Secci, P. Caboni, M. Arca, R. Guillot, T. Boddaert, D. J. Aitken and A. Frongia, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02567J

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