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Issue 48, 2017
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A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines

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Abstract

A three component reaction with two different ketones and aromatic amines was firstly investigated. The difference in reactivity between ordinary ketones and ketone esters allowed for the production of 1,2-DHQs efficiently. The possible Skraup reaction with 2 equiv. of the same ketones was prohibited due to the fast formation of imines.

Graphical abstract: A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines

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Publication details

The article was received on 16 Oct 2017, accepted on 20 Nov 2017 and first published on 20 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02554H
Citation: Org. Biomol. Chem., 2017,15, 10167-10171
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    A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines

    G. Yang, G. Li, J. Huang, Z. Tang and J. Zhao, Org. Biomol. Chem., 2017, 15, 10167
    DOI: 10.1039/C7OB02554H

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