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Issue 45, 2017
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Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters

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Abstract

Amide- and carbamate-linked dendrimeric oligomers are reported as molecular transporters. They effectively complex with pDNA and transport it into cells at an efficiency superior to Lipofectamine, when complexation is carried out by incubation overnight. The carbamate-linked K2C is superior to amide-linked K2A; their pDNA complexes have very low associated cytotoxicity.

Graphical abstract: Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters

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Publication details

The article was received on 16 Oct 2017, accepted on 30 Oct 2017 and first published on 30 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02552A
Citation: Org. Biomol. Chem., 2017,15, 9579-9584
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    Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters

    A. K. Yadav, N. Dey, S. Chattopadhyay, M. Ganguli and M. Fernandes, Org. Biomol. Chem., 2017, 15, 9579
    DOI: 10.1039/C7OB02552A

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