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Issue 47, 2017
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Acid-catalyzed reaction of 2-hydroxycyclobutanone with benzylic alcohols

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Abstract

The acid-promoted syntheses of 2-(benzyloxy)cyclobutanones and bis(benzyloxy)dioxatricyclo decanes were achieved starting from 2-hydroxycyclobutanone and variously functionalized benzyl alcohols. The reaction sequences afforded the desired products in good to high yields and in a solvent-dependent chemoselective fashion.

Graphical abstract: Acid-catalyzed reaction of 2-hydroxycyclobutanone with benzylic alcohols

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Publication details

The article was received on 14 Oct 2017, accepted on 09 Nov 2017 and first published on 10 Nov 2017


Article type: Paper
DOI: 10.1039/C7OB02545A
Citation: Org. Biomol. Chem., 2017,15, 10053-10063
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    Acid-catalyzed reaction of 2-hydroxycyclobutanone with benzylic alcohols

    A. Martis, A. Luridiana, A. Frongia, M. Arca, G. Sarais, D. J. Aitken, R. Guillot and F. Secci, Org. Biomol. Chem., 2017, 15, 10053
    DOI: 10.1039/C7OB02545A

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