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Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor

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Abstract

We report herein the specific sensing of dimeric H45 G-quadruplex DNA via a fluorescence light-up response using fluorescent tetrazolylpyrene nucleoside (TzPyBDo) as a probe. The strong binding of the probe via an intercalative stacking interaction inside the connecting loop of two G-quadruplex units of H45 and the discrimination to other monomeric and long DNA duplexes are accompanied by a drastic enhancement of the emission intensity without compromising the conformation and stability.

Graphical abstract: Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor

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Publication details

The article was received on 29 Sep 2017, accepted on 23 Oct 2017 and first published on 23 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02433A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor

    S. S. Bag, M. K. Pradhan and S. Talukdar, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02433A

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