Issue 48, 2017

Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor

Abstract

We report herein the specific sensing of dimeric H45 G-quadruplex DNA via a fluorescence light-up response using fluorescent tetrazolylpyrene nucleoside (TzPyBDo) as a probe. The strong binding of the probe via an intercalative stacking interaction inside the connecting loop of two G-quadruplex units of H45 and the discrimination to other monomeric and long DNA duplexes are accompanied by a drastic enhancement of the emission intensity without compromising the conformation and stability.

Graphical abstract: Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor

Supplementary files

Article information

Article type
Communication
Submitted
29 Sep 2017
Accepted
23 Oct 2017
First published
23 Oct 2017

Org. Biomol. Chem., 2017,15, 10145-10150

Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor

S. S. Bag, M. K. Pradhan and S. Talukdar, Org. Biomol. Chem., 2017, 15, 10145 DOI: 10.1039/C7OB02433A

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