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Na2S mediated synthesis of terminal alkynes from gem-dibromoalkenes

Abstract

Na2S-mediated facile synthesis of terminal alkynes from gem- dibromoalkenes, at 20/40 ¬°C under open flask conditions has been developed. Various precursors derived from heteroaromatic/aromatic/aliphatic aldehydes were found compatible. The reaction is proposed to go through the Fritsch-Buttenberg-Wiechell (FBW) rearrangement involving the corresponding vinyl carbene. Mild reaction conditions using inexpensive Na2S.9H2O under air, are significant advantages over earlier routes

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Publication details

The article was received on 29 Sep 2017, accepted on 14 Nov 2017 and first published on 14 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02431B
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Na2S mediated synthesis of terminal alkynes from gem-dibromoalkenes

    R. M. Singh, D. Nandini, K. C. Bharadwaj, T. Gupta and R. P. Singh, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB02431B

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