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Regioselective three-component synthesis of 2,3-disubstituted quinolines via the enaminone modified Povarov reaction

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Abstract

The regioselective construction of functionalized quinolines by the three-component reactions of enaminones, aldehydes and anilines is accomplished. Unlike conventional Povarov reactions employing terminal alkynes or alkenes as C3–C4 fragment sources which provide 2,4-disubstituted quinolines, the present method allows fast and regioselective formation of 2,3-disubstituted quinolines as a modified new version of the Povarov reaction.

Graphical abstract: Regioselective three-component synthesis of 2,3-disubstituted quinolines via the enaminone modified Povarov reaction

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Publication details

The article was received on 27 Sep 2017, accepted on 31 Oct 2017 and first published on 31 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02411H
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Regioselective three-component synthesis of 2,3-disubstituted quinolines via the enaminone modified Povarov reaction

    Y. Li, X. Cao, Y. Liu and J. Wan, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02411H

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