Jump to main content
Jump to site search


Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides

Author affiliations

Abstract

Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a highly regioselective gold-catalyzed hydroalkoxylation of internal alkynes and puts forward the utility of the difluoromethylene unit as a directing group in catalysis.

Graphical abstract: Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Sep 2017, accepted on 07 Nov 2017 and first published on 13 Nov 2017


Article type: Paper
DOI: 10.1039/C7OB02406A
Citation: Org. Biomol. Chem., 2017, Advance Article
  •   Request permissions

    Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides

    J. Hamel, T. Hayashi, M. Cloutier, P. R. Savoie, O. Thibeault, M. Beaudoin and J. Paquin, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02406A

Search articles by author

Spotlight

Advertisements