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Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections

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Abstract

The emergence of antibiotic resistance coupled with the lack of investment by pharmaceutical companies necessitates a new look at how we tackle bacterial infections. An intriguing tactic is the interruption of bacterial communication systems. This non-biocidal approach would circumvent the evolutionary pressure on bacteria to mutate and develop resistance. In many pathogenic microorganisms, communication systems, collectively termed quorum sensing (QS), have been observed to control a number of bacterial behaviours including expression of virulence factors and the development of biofilms. QS signalling molecules and their biomimetics, therefore, represent a rational target for the disruption of cooperative behaviour and thus the development of novel antimicrobial strategies. Herein we review recent developments towards the interference of Pseudomonas aeruginosa QS using signalling molecules and their mimetics.

Graphical abstract: Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections

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Publication details

The article was received on 25 Sep 2017, accepted on 17 Oct 2017 and first published on 02 Nov 2017


Article type: Review Article
DOI: 10.1039/C7OB02395B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections

    E. Ó Muimhneacháin, F. J. Reen, F. O'Gara and G. P. McGlacken, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02395B

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