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Water-soluble and UV traceable isatoic anhydride-based reagents for bioconjugation

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Abstract

Isatoic anhydride is elaborated to water soluble bioconjugation reagents that gives functionality and water solubility in one self-cleaning step. This new platform offers high atom economy with carbon dioxide being the only byproduct, and is shown to very quickly and efficiently label proteins in bicarbonate buffered solutions.

Graphical abstract: Water-soluble and UV traceable isatoic anhydride-based reagents for bioconjugation

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Publication details

The article was received on 22 Sep 2017, accepted on 04 Nov 2017 and first published on 06 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02377D
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Water-soluble and UV traceable isatoic anhydride-based reagents for bioconjugation

    A. Fessler, C. Garmon, T. Heavey, A. Fowler and C. Ogle, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02377D

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