Jump to main content
Jump to site search


Visible-light-mediated direct difluoromethylation of alkynoates: Synthesis of 3-difluoromethylated coumarins

Abstract

A photoredox-catalyzed direct difluoromethylation of alkynoates has been developed. The well-designed photoredox system induces a single-step, regioselective installation of a CF2H onto alkynes. Difluoromethyl sulfone was used as an easy to handle CF2H radical source to afford the desired 3-difluoromethylated coumarins in moderate to good yields via radical-triggered tandem difluoromethylation/5-exo cyclization/ ester migration process.

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Sep 2017, accepted on 12 Oct 2017 and first published on 12 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02366A
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
  •   Request permissions

    Visible-light-mediated direct difluoromethylation of alkynoates: Synthesis of 3-difluoromethylated coumarins

    M. Zhu, W. Fu, Z. Wang, C. Xu and B. Ji, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB02366A

Search articles by author

Spotlight

Advertisements