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1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water

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Abstract

A variety of terminal alkenes were converted to the corresponding amides in yields of 25 to 86% in water via treatment with 1,3-dibromo-5,5-dimethylhydantoin, followed by reaction with molecular iodine and aq. NH3 (or amine) in one pot. This metal- and organic solvent-free protocol is not only suitable for styrene derivatives, but also, for the first time, works well on terminal aliphatic alkenes.

Graphical abstract: 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water

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Publication details

The article was received on 18 Sep 2017, accepted on 08 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7OB02329D
Citation: Org. Biomol. Chem., 2017, Advance Article
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    1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water

    C. Ma, G. Fan, P. Wu, Z. Li, Y. Zhou, Q. Ding and W. Zhang, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02329D

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