Jump to main content
Jump to site search


Straightforward synthesis of Man9, the relevant epitope of the high-mannose oligosaccharide

Author affiliations

Abstract

The high-mannose oligosaccharide (or its corresponding Man9 epitope) is the most abundant structure present in pathogen envelope glycoproteins. These glycans play a key role in the pathogenesis of several pathogens and also in the communication with the immune system. Understanding the mechanism of action of these glycans requires the access to pure and chemically well-defined structures in reasonable amounts. The synthesis of these complex branched oligosaccharides is not trivial and few syntheses are reported in the literature with several synthetic and purification steps and low overall yields. In this work, we described a very efficient synthetic alternative to access this relevant Man9 epitope in a very straightforward manner.

Graphical abstract: Straightforward synthesis of Man9, the relevant epitope of the high-mannose oligosaccharide

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Sep 2017, accepted on 08 Oct 2017 and first published on 09 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02286G
Citation: Org. Biomol. Chem., 2017, Advance Article
  •   Request permissions

    Straightforward synthesis of Man9, the relevant epitope of the high-mannose oligosaccharide

    J. Ramos-Soriano, M. C. de la Fuente, N. de la Cruz, R. C. Figueiredo, J. Rojo and J. J. Reina, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02286G

Search articles by author

Spotlight

Advertisements