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Issue 45, 2017
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XtalFluor-E® mediated proto-functionalization of N-vinyl amides: access to N-acetyl N,O-acetals

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Abstract

XtalFluor-E® has been extensively used in a broad range of reactions in the past few years. Here we report its use with protic nucleophiles in a catalytic manner for the in situ generation of protons that lead to the proto-functionalization of activated olefins. Utilizing the latter protocol, proto etherification of enamides gives rise to N,O-acetals in nearly quantitative yields.

Graphical abstract: XtalFluor-E® mediated proto-functionalization of N-vinyl amides: access to N-acetyl N,O-acetals

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Publication details

The article was received on 12 Sep 2017, accepted on 02 Oct 2017 and first published on 24 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02283B
Citation: Org. Biomol. Chem., 2017,15, 9570-9574
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    XtalFluor-E® mediated proto-functionalization of N-vinyl amides: access to N-acetyl N,O-acetals

    Y. Yi, H. Gholami, M. G. Morrow and B. Borhan, Org. Biomol. Chem., 2017, 15, 9570
    DOI: 10.1039/C7OB02283B

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