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Issue 41, 2017
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Hydroxylation of anilides by engineered cytochrome P450BM3

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Abstract

Biocatalytic direct monohydroxylation of anilides has been achieved on preparative scale using mutant cytochrome P450BM3 enzymes. Representative mono- and disubstituted N-trifluoromethanesulfonyl anilides are shown to be converted in most cases to the corresponding 4-hydroxy derivatives, with substituent hydroxylation also occurring in two cases. By mutation variation, it is possible to achieve selective hydroxylation of either ring- or side-chain sites.

Graphical abstract: Hydroxylation of anilides by engineered cytochrome P450BM3

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Publication details

The article was received on 05 Sep 2017, accepted on 03 Oct 2017 and first published on 03 Oct 2017


Article type: Paper
DOI: 10.1039/C7OB02236K
Citation: Org. Biomol. Chem., 2017,15, 8780-8787
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    Hydroxylation of anilides by engineered cytochrome P450BM3

    J. A. O'Hanlon, X. Ren, M. Morris, L. L. Wong and J. Robertson, Org. Biomol. Chem., 2017, 15, 8780
    DOI: 10.1039/C7OB02236K

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