Issue 40, 2017

Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions

Abstract

The copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild conditions. The optimized conditions were also found to be suitable for the N-alkylation of sulfoximine with different alkylboronic acids. In addition, N-methylation and cyclopropylation of the bioactive L-methionine sulfoximine derivative was demonstrated under standard reaction conditions.

Graphical abstract: Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions

Supplementary files

Article information

Article type
Communication
Submitted
05 Sep 2017
Accepted
20 Sep 2017
First published
20 Sep 2017

Org. Biomol. Chem., 2017,15, 8493-8498

Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions

S. Gupta, P. Chaudhary, N. Muniyappan, S. Sabiah and J. Kandasamy, Org. Biomol. Chem., 2017, 15, 8493 DOI: 10.1039/C7OB02234D

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