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Issue 40, 2017
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Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions

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Abstract

The copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild conditions. The optimized conditions were also found to be suitable for the N-alkylation of sulfoximine with different alkylboronic acids. In addition, N-methylation and cyclopropylation of the bioactive L-methionine sulfoximine derivative was demonstrated under standard reaction conditions.

Graphical abstract: Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions

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Publication details

The article was received on 05 Sep 2017, accepted on 20 Sep 2017 and first published on 20 Sep 2017


Article type: Communication
DOI: 10.1039/C7OB02234D
Citation: Org. Biomol. Chem., 2017,15, 8493-8498
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    Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions

    S. Gupta, P. Chaudhary, N. Muniyappan, S. Sabiah and J. Kandasamy, Org. Biomol. Chem., 2017, 15, 8493
    DOI: 10.1039/C7OB02234D

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