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Issue 41, 2017
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Visible-light induced di- and trifluoromethylation of N-benzamides with fluorinated sulfones for the synthesis of CF2H/CF3-containing isoquinolinediones

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Abstract

A general visible light induced direct difluoromethylation of N-methacryloyl benzamides by using difluoromethyl sulfone was developed. In addition, photoredox-catalyzed trifluoromethylation of N-methacryloyl benzamides with trifluoromethyl sulfone via a similar radical process was also achieved. This method allows for an efficient and practical synthesis of a variety of CF2H/CF3-containing isoquinoline-1,3(2H,4H)-diones in moderate to good yields. The reaction features mild reaction conditions, operational simplicity, and a broad substrate scope.

Graphical abstract: Visible-light induced di- and trifluoromethylation of N-benzamides with fluorinated sulfones for the synthesis of CF2H/CF3-containing isoquinolinediones

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Publication details

The article was received on 05 Sep 2017, accepted on 02 Oct 2017 and first published on 02 Oct 2017


Article type: Paper
DOI: 10.1039/C7OB02226C
Citation: Org. Biomol. Chem., 2017,15, 8748-8754
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    Visible-light induced di- and trifluoromethylation of N-benzamides with fluorinated sulfones for the synthesis of CF2H/CF3-containing isoquinolinediones

    G. Zou and X. Wang, Org. Biomol. Chem., 2017, 15, 8748
    DOI: 10.1039/C7OB02226C

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