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Unprecedented 22,26-seco physalins from Physalis angulata and their anti-inflammatory potential

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Abstract

Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC50 values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.

Graphical abstract: Unprecedented 22,26-seco physalins from Physalis angulata and their anti-inflammatory potential

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Publication details

The article was received on 01 Sep 2017, accepted on 29 Sep 2017 and first published on 29 Sep 2017


Article type: Communication
DOI: 10.1039/C7OB02205K
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Unprecedented 22,26-seco physalins from Physalis angulata and their anti-inflammatory potential

    C. Sun, M. B. Oppong, F. Zhao, L. Chen and F. Qiu, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02205K

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