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Issue 38, 2017
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Room-temperature Cu-catalyzed N-arylation of aliphatic amines in neat water

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Abstract

A room-temperature and PTC-free copper-catalyzed N-arylation of aliphatic amines in neat water has been developed. Using a combination of CuI and 6,7-dihydroquinolin-8(5H)-one oxime as the catalyst and KOH as the base, a wide range of aliphatic amines are arylated with various aryl and heteroaryl halides to give the corresponding products in up to 95% yield.

Graphical abstract: Room-temperature Cu-catalyzed N-arylation of aliphatic amines in neat water

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Publication details

The article was received on 25 Aug 2017, accepted on 11 Sep 2017 and first published on 11 Sep 2017


Article type: Communication
DOI: 10.1039/C7OB02126G
Citation: Org. Biomol. Chem., 2017,15, 8009-8012
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    Room-temperature Cu-catalyzed N-arylation of aliphatic amines in neat water

    D. Wang, Y. Zheng, M. Yang, F. Zhang, F. Mao, J. Yu and X. Xia, Org. Biomol. Chem., 2017, 15, 8009
    DOI: 10.1039/C7OB02126G

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