Jump to main content
Jump to site search


Synthesis of functionalized indolizines via gold(I)-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes

Author affiliations

Abstract

A gold-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes has been developed. This method provides a concise and straightforward route to functionalized indolizines through the construction of the pyridine ring of indolizines and also allows elaboration of its pyrrole moiety with or without functional groups. In addition, a wide variety of functional groups, such as aryl, alkenyl, alkynyl, pyridyl or thienyl groups, can be easily incorporated into the pyridine unit of the indolizine products under mild conditions. The utility of the indolizine products was demonstrated by their efficient transformations into various C3-functionalized indolizine derivatives.

Graphical abstract: Synthesis of functionalized indolizines via gold(i)-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Aug 2017, accepted on 05 Sep 2017 and first published on 05 Sep 2017


Article type: Paper
DOI: 10.1039/C7OB02102J
Citation: Org. Biomol. Chem., 2017, Advance Article
  •   Request permissions

    Synthesis of functionalized indolizines via gold(I)-catalyzed intramolecular hydroarylation/aromatization of pyrrole-ynes

    X. Li, J. Zhao, X. Xie and Y. Liu, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02102J

Search articles by author

Spotlight

Advertisements