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Issue 45, 2017
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A general method of Suzuki–Miyaura cross-coupling of 4- and 5-halo-1,2,3-triazoles in water

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Abstract

A general method of the synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by Suzuki–Miyaura cross-coupling from 4- and 5-halo-1,2,3-triazoles is reported. The reaction is mediated by an expanded-ring N-heterocyclic carbene palladium complex in water. The developed reaction protocol meets the requirements of “green chemistry”. Cross-coupling of 4- and 5-chlorotriazoles is reported for the first time.

Graphical abstract: A general method of Suzuki–Miyaura cross-coupling of 4- and 5-halo-1,2,3-triazoles in water

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Publication details

The article was received on 22 Aug 2017, accepted on 31 Oct 2017 and first published on 31 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02091K
Citation: Org. Biomol. Chem., 2017,15, 9575-9578
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    A general method of Suzuki–Miyaura cross-coupling of 4- and 5-halo-1,2,3-triazoles in water

    P. S. Gribanov, G. A. Chesnokov, M. A. Topchiy, A. F. Asachenko and M. S. Nechaev, Org. Biomol. Chem., 2017, 15, 9575
    DOI: 10.1039/C7OB02091K

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