Issue 37, 2017

Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction

Abstract

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels–Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between “drug-like” molecules and natural products.

Graphical abstract: Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction

Supplementary files

Article information

Article type
Communication
Submitted
18 Aug 2017
Accepted
06 Sep 2017
First published
11 Sep 2017

Org. Biomol. Chem., 2017,15, 7758-7764

Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction

S. Llona-Minguez, A. Throup, E. Steiner, M. Lightowler, S. Van der Haegen, E. Homan, L. Eriksson, P. Stenmark, A. Jenmalm-Jensen and T. Helleday, Org. Biomol. Chem., 2017, 15, 7758 DOI: 10.1039/C7OB02069D

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