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Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction

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Abstract

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels–Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between “drug-like” molecules and natural products.

Graphical abstract: Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction

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Publication details

The article was received on 18 Aug 2017, accepted on 06 Sep 2017 and first published on 11 Sep 2017


Article type: Communication
DOI: 10.1039/C7OB02069D
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction

    S. Llona-Minguez, A. Throup, E. Steiner, M. Lightowler, S. Van der Haegen, E. Homan, L. Eriksson, P. Stenmark, A. Jenmalm-Jensen and T. Helleday, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02069D

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