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Copper-catalyzed ipso-selenation of aromatic carboxylic acids

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Abstract

The copper-catalyzed decarboxylative selenation of aromatic carboxylic acids with diselenide is reported. This transformation tolerated a diverse set of functional groups on the substrates, including pentafluorobenzoic acid and heteroaromatic acids, delivering diaryl and methyl aryl selenides in good to excellent yields. Mechanistic studies indicated that the copper catalyst is essential in the activation of the Se–Se bond and the decarboxylation of aromatic acids. The utility of the products has been demonstrated in the facile synthesis of 10H-phenoselenazine and 11-methyldibenzo-(b,f)-1,4-selenazepine.

Graphical abstract: Copper-catalyzed ipso-selenation of aromatic carboxylic acids

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Publication details

The article was received on 18 Aug 2017, accepted on 31 Oct 2017 and first published on 13 Nov 2017


Article type: Paper
DOI: 10.1039/C7OB02066J
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Copper-catalyzed ipso-selenation of aromatic carboxylic acids

    J. Wang, H. Li, T. Leng, M. Liu, J. Ding, X. Huang, H. Wu, W. Gao and G. Wu, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02066J

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