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Issue 40, 2017
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The carolactam strategy is ineffective: synthesis and biological evaluation of carolactam

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Abstract

Carolacton, a secondary metabolite isolated from the extracts of Sorangium cellulosum, causes membrane damage and cell death in biofilms of the caries- and endocarditis-associated bacterium Streptococcus mutans and Streptococcus pneumoniae. It is known that macrolactam derivatives can show improved pharmacological properties compared to the corresponding macrolactons (lactam strategy). Therefore, we here report the total synthesis and biological activity of the lactam derivative of carolacton (“carolactam”). Carolactam was inactive against planktonic cultures of S. pneumoniae and caused damage of S. mutans biofilms at high concentrations only (above 10 μM). Preliminary modeling studies indicate substantial conformational differences between carolacton and carolactam.

Graphical abstract: The carolactam strategy is ineffective: synthesis and biological evaluation of carolactam

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Publication details

The article was received on 18 Aug 2017, accepted on 25 Sep 2017 and first published on 25 Sep 2017


Article type: Paper
DOI: 10.1039/C7OB02060K
Citation: Org. Biomol. Chem., 2017,15, 8553-8558
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    The carolactam strategy is ineffective: synthesis and biological evaluation of carolactam

    J. Ammermann, T. Schmidt, J. Donner, M. Reck, M. Dalton, N. Stumpp, M. Stiesch, I. Wagner-Döbler and A. Kirschning, Org. Biomol. Chem., 2017, 15, 8553
    DOI: 10.1039/C7OB02060K

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