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Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides

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Abstract

A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed reaction under controlled conditions, three novel types of quinoline derivatives were formed via amidation, lactamization or carbamate formation along with the formation of C–C, C–N, and C–O bonds in a one-pot procedure.

Graphical abstract: Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides

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Publication details

The article was received on 16 Aug 2017, accepted on 09 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7OB02043K
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides

    M. Shiri, M. Ranjbar, Z. Yasaei, F. Zamanian and B. Notash, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02043K

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