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Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

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Abstract

Three divergent Direct Imine Acylation (DIA) procedures are reported that allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones (via a novel three-component coupling) from imine and carboxylic acid precursors. All operate via initial N-acyliminium ion formation and diverge depending on the reaction conditions and nature of the substrates.

Graphical abstract: Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

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Publication details

The article was received on 16 Aug 2017, accepted on 29 Aug 2017 and first published on 30 Aug 2017


Article type: Communication
DOI: 10.1039/C7OB02039B
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation

    J. A. Rossi-Ashton, R. J. K. Taylor and W. P. Unsworth, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02039B

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