Jump to main content
Jump to site search


I2-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones

Author affiliations

Abstract

An efficient and applicable I2-catalyzed intramolecular dehydrogenative C–O/C–N coupling reaction via activating the C–H bond adjacent to the N atom has been developed to provide dozens of substituted benzoxazinones (31 examples) and quinazolinones (5 examples) in good to excellent yields (up to 98%). This one-pot methodology has significant advantages, including a metal-free process, broad substrate scope, high atom economy, and simple operation. This strategy goes through an iminium intermediate followed by nucleophilic attack to provide the desired products.

Graphical abstract: I2-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Aug 2017, accepted on 03 Oct 2017 and first published on 03 Oct 2017


Article type: Paper
DOI: 10.1039/C7OB02038D
Citation: Org. Biomol. Chem., 2017, Advance Article
  •   Request permissions

    I2-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones

    K. Chen, B. Gao, Y. Shang, J. Du, Q. Gu and J. Wang, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02038D

Search articles by author

Spotlight

Advertisements