Jump to main content
Jump to site search

Issue 37, 2017
Previous Article Next Article

Metal-free, direct conversion of α-amino acids into α-keto γ-amino esters for the synthesis of α,γ-peptides

Author affiliations

Abstract

An efficient, metal-free synthesis of unusual α-keto γ-amino esters from α-amino acids is achieved by a radical scission–oxidation–addition of silyloxy acrylates procedure, where no purification of the reaction intermediates is needed. This protocol can be applied to the selective modification of the C-terminal position in peptides to give α,γ-hybrids.

Graphical abstract: Metal-free, direct conversion of α-amino acids into α-keto γ-amino esters for the synthesis of α,γ-peptides

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Aug 2017, accepted on 22 Aug 2017 and first published on 23 Aug 2017


Article type: Communication
DOI: 10.1039/C7OB02033C
Citation: Org. Biomol. Chem., 2017,15, 7736-7742
  •   Request permissions

    Metal-free, direct conversion of α-amino acids into α-keto γ-amino esters for the synthesis of α,γ-peptides

    D. Hernández, A. Boto, D. Guzmán and E. Alvarez, Org. Biomol. Chem., 2017, 15, 7736
    DOI: 10.1039/C7OB02033C

Search articles by author

Spotlight

Advertisements