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Issue 44, 2017
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A Cu(II)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-a]pyridines

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Abstract

A copper-promoted cascade decarboxylative halogenation and oxidative diamination reaction sequence of 2-aminopyridines with alkynoic acids has been developed for the synthesis of 2-haloimidazo[1,2-a]pyridines. In this reaction, two C–N bonds and one C-halogen bond are formed in one pot, generating the desired products in good yields. This is the first report on the synthesis of 2-haloimidazo[1,2-a]pyridine derivatives from alkynoic acids.

Graphical abstract: A Cu(ii)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-a]pyridines

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Publication details

The article was received on 14 Aug 2017, accepted on 16 Oct 2017 and first published on 17 Oct 2017


Article type: Paper
DOI: 10.1039/C7OB02014G
Citation: Org. Biomol. Chem., 2017,15, 9311-9318
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    A Cu(II)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-a]pyridines

    Y. Liu, W. Wang, J. Han and J. Sun, Org. Biomol. Chem., 2017, 15, 9311
    DOI: 10.1039/C7OB02014G

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