Jump to main content
Jump to site search

Issue 39, 2017
Previous Article Next Article

Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

Author affiliations

Abstract

The methodology of direct C(sp2)–H functionalization has for the first time been applied as an efficient and advanced approach to carry out C–H/C–H coupling of 2H-imidazole 1-oxides and pyrroles. The atom-economical method used does not require either any auxiliary group in the starting substrates, or catalysis by transition metals. As a result, a number of novel 1H-pyrrol-2-yl-2H-imidazoles, that are particularly of interest in the design of bioactive molecules, have been prepared under mild conditions and in good to excellent yields.

Graphical abstract: Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Aug 2017, accepted on 12 Sep 2017 and first published on 13 Sep 2017


Article type: Communication
DOI: 10.1039/C7OB01999H
Citation: Org. Biomol. Chem., 2017,15, 8280-8284
  •   Request permissions

    Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

    M. Varaksin, T. Moseev, O. Chupakhin, V. Charushin and B. Trofimov, Org. Biomol. Chem., 2017, 15, 8280
    DOI: 10.1039/C7OB01999H

Search articles by author

Spotlight

Advertisements