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Metal-free C-H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

Abstract

Methodology of direct C(sp2)-H functionalization has for the first time been applied as an efficient and advanced approach to carry out C-H/С-H coupling of 2H-imidazole 1-oxides and pyrroles. The atom-economical method used does not require neither any auxiliary group in the staring substrates, nor catalysis by transition metals. As a result, a number of novel 1H-pyrrol-2-yl-2H-imidazoles, that are particularly of interest in the design of bioactive molecules, has been prepared in mild condition and in good to excellent yields.

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Publication details

The article was received on 11 Aug 2017, accepted on 12 Sep 2017 and first published on 13 Sep 2017


Article type: Communication
DOI: 10.1039/C7OB01999H
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    Metal-free C-H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

    M. V. Varaksin, T. D. Moseev, O. N. Chupakhin, V. Charushin and B. A. Trofimov, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB01999H

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