Issue 37, 2017

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Abstract

A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.

Graphical abstract: A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Supplementary files

Article information

Article type
Paper
Submitted
02 Aug 2017
Accepted
29 Aug 2017
First published
29 Aug 2017

Org. Biomol. Chem., 2017,15, 7796-7801

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

J. Shao, R. A. Houghten, C. T. Dooley, M. Cazares, J. P. McLaughlin, S. O. Eans, M. L. Ganno, M. R. Hoot, M. A. Giulianotti and Y. Yu, Org. Biomol. Chem., 2017, 15, 7796 DOI: 10.1039/C7OB01924F

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