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Issue 37, 2017
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A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

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Abstract

A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.

Graphical abstract: A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

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Publication details

The article was received on 02 Aug 2017, accepted on 29 Aug 2017 and first published on 29 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01924F
Citation: Org. Biomol. Chem., 2017,15, 7796-7801
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    A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

    J. Shao, R. A. Houghten, C. T. Dooley, M. Cazares, J. P. McLaughlin, S. O. Eans, M. L. Ganno, M. R. Hoot, M. A. Giulianotti and Y. Yu, Org. Biomol. Chem., 2017, 15, 7796
    DOI: 10.1039/C7OB01924F

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