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Issue 39, 2017
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Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

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Abstract

An Ir(III)-catalyzed regioselective C–H amidation of anilines with sulfonyl azides is described. The developed protocol has good compatibility with diverse functional groups, efficiently providing the monoamidated products with good to excellent yields under mild reaction conditions. Furthermore, the 2-pyrimidyl and sulfonyl moieties in the amidated products can readily be removed, offering the synthetically useful 1,2-diaminobenzene scaffold.

Graphical abstract: Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

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Publication details

The article was received on 31 Jul 2017, accepted on 13 Sep 2017 and first published on 13 Sep 2017


Article type: Paper
DOI: 10.1039/C7OB01899A
Citation: Org. Biomol. Chem., 2017,15, 8302-8307
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    Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

    L. Wang, Z. Yang, M. Yang, R. Zhang, C. Kuai and X. Cui, Org. Biomol. Chem., 2017, 15, 8302
    DOI: 10.1039/C7OB01899A

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