Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

Abstract

An Ir(III)-catalyzed regioselective C–H amidation of anilines with sulfonyl azides is described. The developed protocol has good compatibility with diverse functional groups, efficiently providing the monoamidated products with good to excellent yields under mild reaction conditions. Furthermore, the 2-pyrimidyl and sulfonyl moieties in the amidated products can readily be removed, offering the synthetically useful 1,2-diaminobenzene scaffold.