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Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles

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Abstract

Isoxazoles, as masked 1,3-dicarbonyl equivalents, have proven to be versatile building blocks and pivotal intermediates for the construction of a variety of useful azacycles with molecular complexity. As a result, a range of new reactions have been discovered based on isoxazoles in the past decade. However, the relevant reactions of isoxazoles with alkynes have seldom been explored. In this review, we will focus on the recent progress in the transition-metal-catalyzed formal annulations for the efficient synthesis of N-heterocycles between alkynes and isoxazoles by highlighting their specificity and applicability, and the mechanistic rationale is presented where possible.

Graphical abstract: Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles

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Publication details

The article was received on 31 Jul 2017, accepted on 25 Aug 2017 and first published on 29 Aug 2017


Article type: Review Article
DOI: 10.1039/C7OB01895A
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles

    L. Li, T. Tan, Y. Zhang, X. Liu and L. Ye, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01895A

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