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Issue 34, 2017
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Phosphine-catalyzed intramolecular Rauhut–Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives

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Abstract

A highly enantioselective intramolecular Rauhut–Currier reaction catalyzed by a multifunctional chiral aminophosphine catalyst was reported. A series of hydro-2H-indole derivatives that bear an all-carbon quaternary center were obtained in high yields (up to 94%), and excellent diastereo- and enantioselectivities (up to >20 : 1 dr and >99% ee). And this reaction could be performed on a gram scale using 2 mol% catalyst loading.

Graphical abstract: Phosphine-catalyzed intramolecular Rauhut–Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives

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Publication details

The article was received on 24 Jul 2017, accepted on 09 Aug 2017 and first published on 09 Aug 2017


Article type: Communication
DOI: 10.1039/C7OB01820G
Citation: Org. Biomol. Chem., 2017,15, 7097-7101
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    Phosphine-catalyzed intramolecular Rauhut–Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives

    H. Jin, Q. Zhang, E. Li, P. Jia, N. Li and Y. Huang, Org. Biomol. Chem., 2017, 15, 7097
    DOI: 10.1039/C7OB01820G

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