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Issue 33, 2017
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Forsythenethosides A and B: two new phenylethanoid glycosides with a 15-membered ring from Forsythia suspensa

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Abstract

Forsythenethosides A (1) and B (2), two new phenylethanoid glycosides with an unprecedented 15-membered carbon scaffold ring, were isolated from the fruits of Forsythia suspensa. Their structures, including their geometric configurations, were determined via extensive NMR spectroscopy techniques, especially using 2D NMR data combined with systematic conformational analysis. Forsythenethosides A and B showed strong neuroprotective activities against serum-deprivation-induced PC12 cell damage. Furthermore, they were active on rotenone-induced PC12 cell damage.

Graphical abstract: Forsythenethosides A and B: two new phenylethanoid glycosides with a 15-membered ring from Forsythia suspensa

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Publication details

The article was received on 22 Jul 2017, accepted on 03 Aug 2017 and first published on 09 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01811H
Citation: Org. Biomol. Chem., 2017,15, 7034-7039
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    Forsythenethosides A and B: two new phenylethanoid glycosides with a 15-membered ring from Forsythia suspensa

    S. Shao, Z. Feng, Y. Yang, J. Jiang and P. Zhang, Org. Biomol. Chem., 2017, 15, 7034
    DOI: 10.1039/C7OB01811H

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