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Enantioselective electrophilic cyanation of β-keto amides catalysed by a cinchona organocatalyst

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Abstract

An operationally simple protocol for the enantioselective electrophilic α-cyanation of β-keto amides catalyzed by cinchona-derived catalysts has been demonstrated. The resulting products could be obtained with good to high enantioselectivities (up to 88% ee) and with excellent yields (up to 94%) by employing the mild active 4-acetylphenyl cyanate as the cationic cyano source in the catalytic asymmetric α-cyanation reaction.

Graphical abstract: Enantioselective electrophilic cyanation of β-keto amides catalysed by a cinchona organocatalyst

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Publication details

The article was received on 19 Jul 2017, accepted on 01 Sep 2017 and first published on 01 Sep 2017


Article type: Communication
DOI: 10.1039/C7OB01782K
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Enantioselective electrophilic cyanation of β-keto amides catalysed by a cinchona organocatalyst

    P. G. Karmaker, J. Qiu, D. Wu, M. Reng, Z. Yang, H. Yin and F. Chen, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01782K

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