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Issue 35, 2017
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One-flask synthesis of pyrazolone thioethers involving catalyzed and uncatalyzed thioetherification pathways of pyrazolones

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Abstract

A one-flask thioetherification of pyrazolones has been demonstrated by transforming several pyrazolones to their corresponding 4-mercaptopyrazolone derivatives and employing them towards cross-coupling with various aromatic and heteroaromatic iodides by applying Pd(OAc)2/xantphos as the catalytic system. The coupling ability of these thiol intermediates with 2,3-dichloropyrazine through an aromatic SN2 pathway has also been established. This methodology provides the use of inexpensive starting materials along with a short reaction time.

Graphical abstract: One-flask synthesis of pyrazolone thioethers involving catalyzed and uncatalyzed thioetherification pathways of pyrazolones

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Publication details

The article was received on 17 Jul 2017, accepted on 08 Aug 2017 and first published on 08 Aug 2017


Article type: Communication
DOI: 10.1039/C7OB01754E
Citation: Org. Biomol. Chem., 2017,15, 7267-7271
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    One-flask synthesis of pyrazolone thioethers involving catalyzed and uncatalyzed thioetherification pathways of pyrazolones

    P. Mukherjee and A. R. Das, Org. Biomol. Chem., 2017, 15, 7267
    DOI: 10.1039/C7OB01754E

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