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One-flask synthesis of pyrazolone thioethers involving catalyzed and uncatalyzed thioetherification pathways of pyrazolones

Abstract

A one-flask thioetherification of pyrazolones has been demonstrated by transforming several pyrazolones to their corresponding 4-mercaptopyrazolone derivatives and employing those towards cross-coupling with various aromatic and heteroaromatic iodides by applying Pd(OAc)2/Xantphos as the catalytic system. The coupling ability of these thiol intermediates with 2,3-dichloropyrazine through aromatic SN2 pathway have also been established. The methodology provides use of inexpensive starting materials along with a short reaction time.

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Publication details

The article was received on 17 Jul 2017, accepted on 08 Aug 2017 and first published on 08 Aug 2017


Article type: Communication
DOI: 10.1039/C7OB01754E
Citation: Org. Biomol. Chem., 2017, Accepted Manuscript
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    One-flask synthesis of pyrazolone thioethers involving catalyzed and uncatalyzed thioetherification pathways of pyrazolones

    A. R. Das and P. Mukherjee, Org. Biomol. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7OB01754E

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